Sodium Nitrite Alone Protects the Brain o _i_ Microsomal Ca -ATPase Against Potassium Cyanide-induced Neurotoxicity In Rats

Authors

Odutayo O. Odunuge, Stephen F Austin State UniversityFollow
G.. A. Adenuga

Document Type

Article

Publication Date

1997

Abstract

The effect of a short-term oral administration of potassium cyanide (KCN) (200 ppm in diet) with or without sodium nitrite (NaNO2) pretreatment on rat brain microsomal Ca2* ATPase was investigated. The specific activity value of the enzyme significantly decreased (p<0.05) by 50% compared with control and by 63% for KCN-treated rats compared with KCN-treated rats pretreated with NaNO;,. There was no significant difference at the h = 0.05 level between the values obtained for the control and KCN-treated rats pretreated with NaNO,. These results show both that feeding lowers brain microsomal Ca2f-ATPase activity and that NaNO, has a protective role (antidote function) in that respect.

Comments

Odunuga, OO., & Adenuga, GA (1997), Sodium nitrite alone protects the brain microsomal Ca2+ ATPase against potassium cyanide-induced neurotoxicity in rats. Bioscience Reports 17: 543-546

Repository Citation

Odunuge, Odutayo O. and Adenuga, G.. A., "Sodium Nitrite Alone Protects the Brain o _i_ Microsomal Ca -ATPase Against Potassium Cyanide-induced Neurotoxicity In Rats" (1997). Faculty Publications. 7.
https://scholarworks.sfasu.edu/chemistry_facultypubs/7