Two new compounds, maclurin A (1) and maclurin B (2), and six known ones, ononin (3), pterofuran (4), osajin (5), pomiferin (6), 3,4-dihydroxybenzoic acid (7), and 2,3,4-trihydroxybenzoic acid (8) were isolated from the fruit of Maclura pomifera. Compounds 3 and 4 were isolated from the genus for the first time. Structure elucidation was achieved by spectroscopic measurements and by comparison with literature data. Compounds 2-4 exhibited activities against the cancer cell lines A549 and Panc-28 with GI50 values from 18.1 to 32.2, and 20.6 to 43.5 μM, respectively. Compounds 2 and 4 also showed cytotoxicity against HCT 116 with GI50 values of 47.2 and 24.4 μM, respectively.
Su, Zushang; Wang, Ping; Yuan, Wei; Grant, Greg; and Li, Shiyou, "Phenolics from the Fruits of Maclura pomifera" (2017). NCPC Publications and Patents. 51.
Pharmacology, Toxicology and Environmental Health Commons, Pharmacy and Pharmaceutical Sciences Commons
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Su, Z., Wang, P., Yuan, W., Grant, G., & Li, S. (2017). Phenolics from the Fruits of Maclura pomifera. Natural Product Communications, 12(11), 1743–1745. https://doi.org/10.1177/1934578x1701201122