Title

Ecdysteroids and a Sucrose Phenylpropanoid Ester from Froelichia floridana

Authors

Ping Wang, Stephen F Austin State University, Arthur Temple College of Forestry and AgricultureFollow
Shiyou Li, Stephen F Austin State University, Arthur Temple College of Forestry and AgricultureFollow
Stacy Ownby
Zhizhen Zhang
Wei Yuan, Stephen F Austin State University, Arthur Temple College of Forestry and AgricultureFollow
Wanli Zhang
R. Scott BeasleyFollow

Document Type

Article

Publication Date

2-2009

Abstract

Phytoecdysteroid glycosides (1–5) and a phenylpropanoid ester of sucrose (6) were isolated from the whole plant of Froelichia floridana, along with eight known compounds including three ecdysteroids (7–9), four flavonoids (10–13), and one phenolic compound (14). Structures were determined using a combination of spectroscopic techniques. Compounds 1, 2 and 6–14 were tested in vitro for their activity against human DNA topoisomerase I. Compound 13 (diosmetin) showed marginal inhibition against topoisomerase I with IC₅₀ of 130 μM in conjunction with low intercalation ability.

Comments

Originally published in Phytochemistry (2009) 70(3) DOI: 10.1016/j.phytochem.2009.01.017

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Repository Citation

Wang, Ping; Li, Shiyou; Ownby, Stacy; Zhang, Zhizhen; Yuan, Wei; Zhang, Wanli; and Beasley, R. Scott, "Ecdysteroids and a Sucrose Phenylpropanoid Ester from Froelichia floridana" (2009). NCPC Publications and Patents. 19.
https://scholarworks.sfasu.edu/ncpc_articles/19

DOI

10.1016/j.phytochem.2009.01.017