Date of Award


Degree Type


Degree Name

Master of Science - Natural Sciences


Chemistry and Biochemistry

First Advisor

Dr. Matibur Zamadar

Second Advisor

Dr. Michele Harris

Third Advisor

Dr. Xiaozhen Han

Fourth Advisor

Dr. Robert Friedfeld


Photodynamic therapy (PDT) has become a widely popular therapeutic approach for treating various types of cancer over the past several decades. PDT utilizes a photosensitizer, visible light, and oxygen, to produce reactive oxygen species (ROS) which can be used to treat cancer and inhibit growth of bacteria. In this study, a multifunctional solution that is comprised of Fe(III) ions, cationic meso-tetra(N-methyl-4-pyridyl)porphine tetrachloride (TMPyP), and 1,5-dihydroxynapthalene (1,5-DHN), was shown to produce reactive oxygen species (ROS) such as singlet oxygen (1O2) or hydroxyl radicals (ȮH) in aerobic or anaerobic environments, respectively, and in both environments, 1,5-DHN was oxidized to Juglone or derivatives of Juglone. Moreover, this multifunctional solution was found to generate ȮH and Juglone in a hydrogen peroxide (H2O2) rich environment without the presence of visible light. This multifunctional solution has shown potential as a possible antibacterial agent and photosensitizer for PDT which possesses unique characteristics that can address many of the limitations and challenges in the field of PDT.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.



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