Date of Award
Master of Science - Natural Sciences
Chemistry and Biochemistry
Xiaozhen Han, Ph.D.
J. Brannon Gary, Ph.D.
Michele Harris, Ph.D.
Robert Wiggers, Ph.D.
Matibur Zamadar, Ph.D.
Novel designed metal ligand complexes as prodrugs are useful in the effort to find more effective and selective anti-cancer treatments. Carbon monoxide, CO, is known to induce mitochondrial collapse in cancer cells. Herein is described the synthesis of seven novel bipyridine flavonolate palladium(II) and platinum(II) complexes with the property of releasing carbon monoxide, and their characterization with FTIR, UV-Vis, fluorescence, NMR, and ESI mass spectra. Their ability to release carbon monoxide was investigated through oxygenation reaction under various conditions of temperature and light irradiation. The nitroxygenation reaction of the palladium complexes was also studied with nitrosyl hydride, HNO, generated in situ from Angeli’s salt. Deoxymyoglobin was used to trap CO released from the complexes, and the reaction was monitored spectroscopically. The spectra showed that oxygenation reaction did not produce CO in the palladium complexes but did in the platinum complexes with irradiation, whereas nitroxygenation reaction did in the palladium complexes.
Whitfield, Sarah, "Synthesis and Characterization of Carbon Monoxide Producers Bipyridine Flavonolate Palladium(II) and Platinum(II) Complexes: Potential Anti-Cancer Agents" (2020). Electronic Theses and Dissertations. 291.
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