Date of Award
5-2020
Degree Type
Thesis
Degree Name
Master of Science - Natural Sciences
Department
Chemistry and Biochemistry
First Advisor
Xiaozhen Han, Ph.D.
Second Advisor
J. Brannon Gary, Ph.D.
Third Advisor
Michele Harris, Ph.D.
Fourth Advisor
Robert Wiggers, Ph.D.
Fifth Advisor
Matibur Zamadar, Ph.D.
Abstract
Novel designed metal ligand complexes as prodrugs are useful in the effort to find more effective and selective anti-cancer treatments. Carbon monoxide, CO, is known to induce mitochondrial collapse in cancer cells. Herein is described the synthesis of seven novel bipyridine flavonolate palladium(II) and platinum(II) complexes with the property of releasing carbon monoxide, and their characterization with FTIR, UV-Vis, fluorescence, NMR, and ESI mass spectra. Their ability to release carbon monoxide was investigated through oxygenation reaction under various conditions of temperature and light irradiation. The nitroxygenation reaction of the palladium complexes was also studied with nitrosyl hydride, HNO, generated in situ from Angeli’s salt. Deoxymyoglobin was used to trap CO released from the complexes, and the reaction was monitored spectroscopically. The spectra showed that oxygenation reaction did not produce CO in the palladium complexes but did in the platinum complexes with irradiation, whereas nitroxygenation reaction did in the palladium complexes.
Repository Citation
Whitfield, Sarah, "Synthesis and Characterization of Carbon Monoxide Producers Bipyridine Flavonolate Palladium(II) and Platinum(II) Complexes: Potential Anti-Cancer Agents" (2020). Electronic Theses and Dissertations. 291.
https://scholarworks.sfasu.edu/etds/291
Creative Commons License
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