Date of Award


Degree Type


Degree Name

Master of Science - Natural Sciences


Chemistry and Biochemistry

First Advisor

Xiaozhen Han, Ph.D.

Second Advisor

J. Brannon Gary, Ph.D.

Third Advisor

Michele Harris, Ph.D.

Fourth Advisor

Robert Wiggers, Ph.D.

Fifth Advisor

Matibur Zamadar, Ph.D.


Novel designed metal ligand complexes as prodrugs are useful in the effort to find more effective and selective anti-cancer treatments. Carbon monoxide, CO, is known to induce mitochondrial collapse in cancer cells. Herein is described the synthesis of seven novel bipyridine flavonolate palladium(II) and platinum(II) complexes with the property of releasing carbon monoxide, and their characterization with FTIR, UV-Vis, fluorescence, NMR, and ESI mass spectra. Their ability to release carbon monoxide was investigated through oxygenation reaction under various conditions of temperature and light irradiation. The nitroxygenation reaction of the palladium complexes was also studied with nitrosyl hydride, HNO, generated in situ from Angeli’s salt. Deoxymyoglobin was used to trap CO released from the complexes, and the reaction was monitored spectroscopically. The spectra showed that oxygenation reaction did not produce CO in the palladium complexes but did in the platinum complexes with irradiation, whereas nitroxygenation reaction did in the palladium complexes.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.



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