Date of Award
Master of Science in Natural Science
Dr. Matibur Zamadar
Dr. Michele Harris
Dr. Russell Franks
Dr. Josephine Taylor
Development of a photosensitizer that can work in both aerobic and anaerobic environments would increase the robustness of the cancer treatment known as photodynamic therapy. The development of a photosensitizer was first attempted by synthesizing a tin (IV) meso-tetra (4-pyridyl) porphyrin dichloride-tetrachlorobis (Bipy)2 ruthenium (II) complex. The synthesize of the tin porphyrin was done by a method from literature and had a percent error of 31.58 and 37.31 when comparing the theoretical percentages of carbon (55.39) and nitrogen (12.92) meaning that photosensitizer was not synthesized.
The second type of chromophore that was studied was 1-nitropyrene do determine if it can act as a possible photosensitizer. As a proof of concept, 1-nitropyrene can act as a photosensitizer by using visible light. Upon visible light irradiation 1-nitropyrene can produce 1O2, ȮH, and possibly NO species under aerobic conditions and can produce ȮH and possibly NO under anaerobic conditions.
Sharp, Phillip, "Syntheses of a Tin (IV) meso-Tetra(4-pyridyl) Porphyrin Dichloride-Tetrachlorobis (Bipy)2 Ruthenium (II) Complex and Studies of Photophysical Properties of 1-Nitropyrene" (2018). Electronic Theses and Dissertations. 224.
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