The direct functionalization of CH bonds has frequently been deemed a “Holy Grail” of organometallic chemistry. A seminal example of this transformation was the demonstration by Shilov and co-workers that platinum(II) salts catalyze the direct oxidation of alkanes into their corresponding alcohols and alkyl halides. Subsequent work in this area has focused on surveying diverse ligands for these reactions in an effort to enhance reactivity and selectivity, slow catalyst decomposition, and replace platinum(IV)-based oxidants with more cost-effective alternatives.[3–5] In a key development, chemists at Catalytica identified [bpymPtCl2] (bpym = bipyrimidine) as a pre-catalyst for the oxidation of CH4 into CH3OSO3H in fuming H2SO4
Gary, J. Brannon, "Platinum and palladium complexes containing cationic ligands as catalysts for arene HID exchange and oxidation." (2010). Faculty Publications. 66.