NCPC Publications and Patents
 

Document Type

Article

Publication Date

12-15-2013

Abstract

Giant salvinia (Salvinia molesta) is one of the most noxious invasive species in the world. Our bioactivity-guided fractionation of ethanol extract of giant salvinia led to the isolation of 50 compounds. Of the six new compounds (16), salviniol (1) is a rare abietane diterpene with a new ferruginol-menthol coupled skeleton and both salviniside I (2) and salviniside II (3) are novel benzofuran glucose conjugates with unique 10-membered macrodiolide structures. Sixteen abietane diterpenes (1, 717, and 1922) demonstrated in vitro activities against human tumor cells, and 7 and 8 showed selective cytotoxicity to tumor cells over normal cells.

Graphical abstract

Bioactivity-guided fractionation of ethanol extract of giant salvinia led to the isolation of 50 compounds including 6 new compounds. The new compound salviniol (1) is a rare abietane diterpene with a new ferruginol–menthol coupled skeleton and both salviniside I (2) and salviniside II (3) are novel benzofuran glucose conjugates with unique 10-membered macrodiolide structure through acylation at C-4 and C-6 of glucopyranosyl. Cytotoxicity of 50 compounds against a panel of six human tumor cell lines was examined in vitro.

Comments

In Bioorganic & Medicinal Chemistry Letters 23(24), 15 December 2013, Pages 6682–6687

doi:10.1016/j.bmcl.2013.10.040

Authorized users may access at:

http://www.sciencedirect.com/science/article/pii/S0960894X13012468

DOI

10.1016/j.bmcl.2013.10.040

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