NCPC Publications and Patents
 

Title

Ecdysteroids and a Sucrose Phenylpropanoid Ester from Froelichia floridana

Document Type

Article

Publication Date

2-2009

Abstract

Phytoecdysteroid glycosides (15) and a phenylpropanoid ester of sucrose (6) were isolated from the whole plant of Froelichia floridana, along with eight known compounds including three ecdysteroids (79), four flavonoids (1013), and one phenolic compound (14). Structures were determined using a combination of spectroscopic techniques. Compounds 1, 2 and 614 were tested in vitro for their activity against human DNA topoisomerase I. Compound 13 (diosmetin) showed marginal inhibition against topoisomerase I with IC50 of 130 μM in conjunction with low intercalation ability.

Comments

Originally published in Phytochemistry (2009) 70(3) DOI: 10.1016/j.phytochem.2009.01.017

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DOI

10.1016/j.phytochem.2009.01.017

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