Reversal of Sodium Arsenite Inhibition of Rat Liver Microsomal Ca2+ Pumping ATPase by Vitamin C

Authors

Odutayo O. Odunuge, Stephen F Austin State UniversityFollow
Gbolahan W. Okunade
Olufunso O. Olorunsogo

Document Type

Article

Publication Date

1999

Abstract

Sodium arsenite (NaAsO2), at 10% of its median lethal dose, was administered to rats with and without vitamin C pretreatment. Liver microsomal fraction was isolated and the activity of Ca2+-ATPase was assayed. Sodium arsenite was found to inhibit the activity of the liver microsomal Ca2+-ATPase to 50% to that of control rats. The specific activity of the enzyme in rats administered sodium arsenite with vitamin C pretreatment was not significantly different from that of control rats.

Comments

Odunuga, OO., Okunade, WG., & Olorunsogo, OO (1999), Reversal of sodium arsenite inhibition of rat liver microsomal Ca2+ pumping ATPase by vitamin C. Bioscience Reports 19: 11-15

Repository Citation

Odunuge, Odutayo O.; Okunade, Gbolahan W.; and Olorunsogo, Olufunso O., "Reversal of Sodium Arsenite Inhibition of Rat Liver Microsomal Ca2+ Pumping ATPase by Vitamin C" (1999). Faculty Publications. 6.
https://scholarworks.sfasu.edu/chemistry_facultypubs/6